Patient handout · Pain treatments
Alpha-2-Macroglobulin (A2M) Therapy
What it is
A2M is a protein found in your blood. For this treatment, it is collected from your blood and injected into a joint or disc. Research is very limited, and results vary.
This treatment is usually self-pay. It is not FDA-approved to treat a specific condition, and research is still evolving. No result can be promised. We give you a written cost estimate first.
Why it is done
- Selected patients with osteoarthritis
- Patients who understand the early-stage evidence and self-pay costs
What to expect
- Before: We talk about your goals and review your imaging. You get a written cost estimate before treatment.
- During: Blood is drawn and processed to collect the protein. It is then injected into the joint or disc.
- After: Rest the area as told, then slowly increase activity.
Self-care tips
- Follow your rest and activity plan closely.
- Ask before taking anti-inflammatory pain medicines, like ibuprofen. You may need to avoid them for a time.
- Ice may ease soreness, but ask us first.
- Results, if they come, may take weeks to show.
When to call us
- Fever or chills
- Redness, swelling, warmth or drainage where the needle went in
- Pain that is much worse than before, or new weakness or numbness
- Pain or swelling that keeps getting worse
Call 911 for trouble breathing, chest pain, or loss of bladder or bowel control.
This handout is general information and is not a substitute for medical advice.